The outcome of the research found out 8/33 fetuses had bilateral nasal bone absence and two had unilateral absence. As a result of absence of the nasal borne through use of radiographic diagnosis, histological no nasal borne can be found. Therefore, research result that showed absence of the nasal bone implies that fetuses had delayed maturation associated with Down syndrome. Moreover, there is a high possibility to deduce genotypic differences through these phenotypic differences in nasal bone appearance within fetuses with Down syndrome (Duyune S et al, 2001).
According to (Trimble BK, Baird PA, 2008), they conducted a research in the AFP (Alpha feto-protein) in the fetuses that were diagnosed for DS. Ideally, AFP is plasma protein that is produced by the liver and yolk sac during the fetal period. The essence of the using the APF to study abnormality in fetus development by Trimble BK, Baird PA (2008), it is because betahCG serum and APF concentrations are use in screening for DS in these second trimester of pregnancy. Therefore, studying the variation of the Alpha feto-protein between the control group and DS fetus help identify the abnormal development. Fortunately in their study Trimble BK, Baird PA (2008), reported that there was a new mutation in exon 5 of the Alpha feto-protein (AFP) gene.
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